Genetics of canine cranial cruciate ligament rupture
Abstract
The review of the literature shows that CCLD is a multifactorial disease, but nonetheless also
a genetic disease. Mostly pure breeds are affected, the top breeds affected with CCLD are
Newfoundland, Rottweiler and Labrador retriever. Bilateral ruptures are very common, this
points in the direction of a premature pathological degenerative disease, which one expects
with an inherited disease, most ruptures are chronic ruptures, not acute-injury or trauma
induced, the ruptures occur within normal activity-level. Most ruptures occur at too young of
an age for it be explained by physiological aging process. The mean age of CCLR is reported
to be between 4,3 -7,7 in the different published studies.