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dc.contributor.authorLévai, Réka
dc.contributor.authorBarna, Tímea
dc.contributor.authorFábián, Katalin
dc.contributor.authorBlome, Sandra
dc.contributor.authorBelák, Katinka
dc.contributor.authorBálint, Ádám
dc.contributor.authorKoenen, Frank
dc.contributor.authorKulcsár, Gábor
dc.contributor.authorFarsang, Attila
dc.date.accessioned2020-11-27T09:42:09Z
dc.date.available2020-11-27T09:42:09Z
dc.date.issued2019-04
dc.identifier.citationMagyar Állatorvosok Lapja 141(4), 227-243. (2019)en_US
dc.identifier.urihttp://hdl.handle.net/10832/2521
dc.description.abstractSUMMARY Background: Classical swine fever (CSF) or hog cholera is a highly contagious and devastating disease of Suidae caused by an enveloped single-stranded RNA virus (CSFV) of the family Flaviviridae, genus Pestivirus. CSF has vast economic and trade significance all over the world, and it has the massive potential to spread rapidly from country to country. This is the reason why the World Organisation for Animal Health has listed CSF as a Notifiable Disease and it is also considered a transboundary animal disease.Objective: The objective of the present studies was to determine the efficacy of a single dose of a newly developed marker vaccine candidate against CSF, administered intramuscularly or orally in 6-week-old domestic piglets with and without maternally derived antibodies (MDAs) against Pestiviruses, to provide protection against a challenge with the highly virulent CSFV strain “Koslov” 14 days post vaccination. Materials and Methods: In both experiments two test groups were formed with 15 animals each, one group for intramuscular (im.), while another one for oral (p.o.) immunisation. The control groups contained 10 animals as unvac-cinated controls, respectively. All piglets were oronasally challenged with the highly virulent CSF virus (CSFV) strain “Koslov” 14 days post-vaccination. Results and Discussion: The vaccine candidate when administered im. provided complete protection in MDA- animals, while p.o. administration triggered only partial protection. Furthermore, we found that the presence of the MDAs had negative effect on the efficacy of the vaccine candidate. However, this was greatly influenced by the route of administration. Based on our observations, im. administration is recommended to achieve better immune response during the CSF control programs. The vaccine candidate met the criteria of Ph. Eur Mono-graph 0065, “Swine-fever vaccine (live, prepared in cell cultures), classical” 7th Edition. Fulfilling these validity criteria is a key step in the registration procedure for a vaccine candidate.en_US
dc.language.isohuen_US
dc.publisherMagyar Állatorvosok Lapjaen_US
dc.titleÚjonnan kifejlesztett, klasszikus sertéspestis elleni markervakcina regisztrációs hatékonysági vizsgálataen_US
dc.title.alternativePre-registration efficacy studies of a novel marker vaccine against classical swine fever on target animalsen_US
dc.typeArticleen_US
dcterms.bibliographicCitationMagyar Állatorvosok Lapja 141(4), 227-243. (2019)


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