A szociális döntéshozatali hálózat vizsgálata valproáttal kezelt, autizmus-modell egerekben

Abstract

The Autism Spectrum Disorder (ASD) is a lifelong neurodevelopmental disease that is extensively prevalent and males are multiple times more affected than females. ASD any degree of severity, is clinically characterized by social behaviour impairments, mainly involving difficulties in non-sexual social situations. Despite a complex genetic background, exposure to specific agents, such as valproic acid (VPA) during pregnancy, have been linked to ASD. In the current experiment I used the VPA-mouse model of ASD, investigating changes of the social decision-making network of brain regions (SDMN) of juvenile male mice in the light of several social settings.