A karprofen és a ketoprofen többnapos alkalmazásának hatása a véralvadási folyamatokra kutyában

Abstract

SUMMARY Given the frequent use of carprofen (CRP) and ketoprofen (KTP) as analgesics in veterinary practice for relieving pain during surgery, the primary objective of this trial was to describe the effects of the latter compounds on the hemostatic profile in dogs after prolonged i.v. administration. All dogs enrolled were subdivided into two groups of each 5; i.e. involving group I (CRP) and group II (KTP) which received intravenously the commercially available injectable formulations of CRP and KTP at the doses of 2.2 mg/kg/day and 3 mg/kg/day bodyweight for 5 days, respectively. In both groups there were dogs with decreased PT values, which were noted 60 min after drug administration, showing a continuous decline. Regarding mean APTT values, there was a continuous decrease in both groups until the 3rd day of the study. Mean APTT values were decreased, showing significant alterations within time (p < 0,01), besides there was a significant group-time interaction (p < 0,01). There were also significant alterations in mean PT values in both groups within time (p < 0,05), whereas time-group interaction was not significant. The F and D-dimer concentrations were within reference ranges in both groups, without significant changes in hemostatic variables throughout the study period. Administration of CRP or KTP for 5 days caused minor but not important alterations in hemostatic variables in healthy dogs, which may encourage the use of these drugs for analgesia during the surgical procedure and for inflammations, when necessary.