Primer vese-adenocarcinoma és Aeromonas hydrophila okozta heveny septicaemia tatár homoki boában (Eryx tataricus)

Abstract

Background: The Tartar sand boa (Eryx tataricus) is considered one of the larger viviparous sandboa species. Neoplasms of the kidney are known in reptiles. Renal adenoma and adenocarcinoma, and expansively growing tubular nephroblastoma have been described. Pan-cytokeratin (CK) immunohistochemical reaction used in human onco-diagnostics has been used successfully for typing renal adenocarcinoma in reptiles. We have not found any reports of renal tumors in sand boas. Materials and Methods: We performed pathological diagnostic tests on a female Tartar sand boa. Columbia blood agar and Drigalski agars plates were inoculated with samples from the liver and kidney. Routine histopathology was performed with hematoxylin and eosin (H&E) staining. In terms of immunohistochemical investigations, pan-cytokeratin and Ki-67 tests were performed. Results and Discussion: The left kidney was a 10cm long, spindle-shaped and easily movable compact structure of greyish white colour during necropsy. The right kidney was normal in appearance. We managed to isolate Aeromonas hydrophila bacteria from the liver and the left kidney. Histological examination on H&E-stained sections from the abnormal kidney did not show any histological structures characteristic of normal kidney. As a sign of mitotic activity, the Ki-67 marker showed several dividing cells. The origin of the epithelial tumour cells was confirmed with a pan-cytokeratin antibody. The definitive diagnosis of solid/ tubulopapillary renal adenocarcinoma of medium mitotic activity was concluded. The tumour did not form metastasis. The cause of death was acute septicaemia caused by Aeromonas hydrophila.