Effects of low and high dosage diphtheria toxin on macrophage ablation in ITGAM mice

Abstract

Over the last few decades, modern technology has opened the door to a new world of possibilities within the field of medical research. Genetic engineering allows scientists to modify an organism’s genome by introducing or deleting DNA segments which code for certain genes. Further developing of this technology has lead to the production of laboratory animals which may be subjected to conditional depletion of certain cell types.