Elsődleges légcső-lymphoma esete macskában Patológiai esetbemutatás

Abstract

SUMMARY Background: Feline tracheal tumours are infrequently reported. In veterinary litera ture only a few case reports are published: tracheal squamous cell carcinoma, -lym phoma, -adenocarcinoma, and tracheobronchial neuroendocrine carcinoma in cats. Objectives: The authors reported a pathological case of primary extranodal tra cheal lymphoma in an 11-year-old castrated male European shorthair cat carcass. Materials and Methods: After macroscopic investigation, the tracheal tissue samples were separated and conserved in 8% formalin for 24 hours at room tem perature, embedded in paraffin wax and further processed for sectioning (3-4 µm) and immunohistochemistry (antibodies: anti-vimentin, -smooth muscle actin (α-SMA), - CD79a, - Ki-67, and - claudin-5). Results and Discussion: The malignant tumour developed at the middle part of the trachea. It was irregular spherical shape, greyish-white, moderately firm, with uneven surface, and 2,5 × 3 cm in diameters. The tumour wrapped around the tra chea, destroyed the cartilages, and protruded into the lumen, causing obturation. Hematoxylin and eosin-stained histologic preparations presented a monomor phic, diffuse (non-follicular) proliferation of the small-sized neoplastic lymphoid cells., with moderate tumour-induced neovascularisation. The mitotic index of this tumour was 3–4 mitotic figures/high power magnification. The tumour cells, showed diffuse intense cytoplasmic vimentin-positivity, diffuse intense CD3- membrane-positivity, α-SMA-, claudin-5- and CD79a-negativities. The Ki-67-la belling index was 34–35%. The definitive diagnosis was primary T-cell tracheal lymphoma. It is the first description of the feline primary tracheal lymphoma in the Hungarian veterinary literature.