Drug absorption modelling in porcine intestinal epithelial cell line

Abstract

Once an active substance has been approved for use,itis often combined withat least oneexcipientduring production of proprietary products. Excipients serve to aid absorptionof active substancesandadditionally contribute to other properties of the active substance includingshelf-life and manufacturing efficiency.Due to this effect onabsorptionof the active substance, and thefact that therapeutic effect of adrugcan be influenced by theabsorbed concentration, it is important to evaluate how specific excipients can alter pharmacokinetics(PK)and pharmacodynamics(PD)of an active substance.