Antibakteriális hatású kísérleti takarmányadalékok hatékonyságának vizsgálata Brachyspira hyodysenteriae-vel fertőzött malacokban

Abstract

SUMMARY Two, non-antibiotic feed additives (Dys-1 and Trial-D1) developed for prevention and alleviation of clinical symptoms of swine dysentery (SD) were studied in an infection model. The feed of two groups (Dys-1, Trial-D1) contained one of the additives and similarly to the third group (T-2) T-2 toxin (2 mg/kg) as well. After 19 days of intake all of the four groups (’Control’ group too which did not consume T-2 toxin and any additives) were inoculated with fresh colon scraping of SD affected pigs via gastric tube. Form, appearance and consistency of faeces following the infection was qualified by a 5-grade (0–4) scoring system. Fisher exact probe demonstrated that frequency of diarrhoea scores depended on treatments. Average live weight and daily weight gain of Dys-1 pigs were found superior to that of the others. Gross pathological lesions of SD were found exclusively in pigs that showed the clinical signs of the disease at the time of exsanguination. Data of the present experiment justifies further improvement of Dys-1 and semi-field trials with the upgraded additive. The infection model, with minor alterations, seems suitable for further studies with SD.