Hazai Francisella tularensis ssp. holarctica törzsek antibiotikumérzékenységének vizsgálata (másodközlés)

Abstract

SUMMARY The etiological agent of the zoonotic bacterial infection, tularaemia, is Francisella tularensis, which is a potential biologocal warfare agent. During the past decade 23–160 human cases a year were reported in Hungary, usually with a history of close contact with rodents or brown hares (Lepus europeus) or tick bites. Infections in humans can be treated by the administration of antibiotics. This article provides information on the in vitro antibiotic susceptibility of F. tularensis ssp. holarctica strains originating from Hungary from 28 European brown hares and a patas monkey (Erythrocebus patas) to 11 antibiotics. All 29 strains were susceptible to aminoglycosides, tetracyclines, quinolones and chloramphenicol, which antibiotics are commonly used in therapy. The strains were also susceptible to rifampicin and tigecycline, while they were resistant to erythromycin and linezolid. Based on the results of the in vitro examinations ciprofloxacin, levofloxacin, doxycycline and gentamycin are recommended as first choice therapy for tularaemia infections in Hungary.