Citokinek az ember és a kutya krónikus bélgyulladásaiban : Irodalmi összefoglaló – Második rész

Abstract

Like human inflammatory bowel disease, canine chronic enteropathies are not a fully understood disease group. Accurate knowledge of the cytokines involved in the inflammatory response can be invaluable in both diagnosis and therapy. In human gastroenterology, considerable attention has been paid to their investigation, but in the veterinary field, there are few clear results so far. The authors describe the immunological background of chronic enteritis that has been mapped so far, mainly in terms of cytokine expression, and summarise the results of studies to date on cytokines specific for similar diseases in dogs. Cytokines are polypeptide hormone-like molecules that enable communication between cells and can foster or limit inflammatory processes. The pathophysiology of chronic inflammatory enteropathy (CIE) in dogs is still only partially delineated, but its understanding could lead to significant advances in the clinical approach to this patient population. Based on the results of studies carried out in the past decades in this area, TNFα, IL1β, IL12, IL23 and IL33 might be of higher importance in initiating inflammation in the bowel and these might have a potential to be used as biomarkers or therapeutic targets in CIE.