Fotoaktív glutamát vegyületek dendritikus integráció méréséhez

Abstract

Photoactive cage molecules can be bound to both excitatory and inhibitory neurotransmitters and their analogues, and used as carrier molecules, thus creating a caged neurotransmitter that is excited when exposed to light, releasing its payload. By combining this technique with fast two-photon microscopy, the fast and localised synaptic transmission patterns between individual neurons can be precisely reproduced both in vitro and in vivo, allowing us to investigate the mechanisms of dendritic integration and signal processing.