Genomic Epidemiology and Evolution of Fowl Adenovirus 1
Megtekintés/ Megnyitás
Dátum
2023Szerző
Jakab, Szilvia
Bali, Krisztina
Homonnay, Zalán
Kaszab, Eszter
Ihász, Katalin
Fehér, Enikő
Mató, Tamás
Kiss, István
Palya, Vilmos
Bányai, Krisztián
DOI link
10.3390/ani13182819Metaadat
Részletes rekordAbsztrakt
Fowl adenovirus 1 (FAdV-1) is the main cause of gizzard erosion in chickens. Whole genome sequencing and sequence analyses of 32 FAdV-1 strains from a global collection provided evidence that multiple recombination events have occurred along the entire genome. In gene-wise phylogenies, only the adenoviral pol gene formed a tree topology that corresponded to whole genome-based phylogeny. Virus genetic features that were clearly connected to gizzard erosion were not identified in our analyses. However, some genome variants tended to be more frequently identified from birds with gizzard erosion and strains isolated from healthy birds or birds with non-specific pathologies tended to form common clusters in multiple gene phylogenies. Our data show that the genetic diversity is greater, and the evolutionary mechanisms are more complex within FAdV-1 than previously thought. The implications of these findings for viral pathogenesis and epidemiology await further investigation.