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dc.contributor.authorJócsák, Gergely
dc.contributor.authorKiss, Dávid Sándor
dc.contributor.authorTóth, István
dc.contributor.authorBárány, Zoltán
dc.contributor.authorZsarnovszky, Attila
dc.contributor.authorFrenyó, V. László
dc.date.accessioned2021-01-21T11:14:23Z
dc.date.available2021-01-21T11:14:23Z
dc.date.issued2017-01
dc.identifier.citationMagyar Állatorvosok Lapja 139(1), 55-63. (2017)en_US
dc.identifier.urihttp://hdl.handle.net/10832/2591
dc.description.abstractSummary The authors present their study on the summarized effects of zearalenone (ZEA) on the mammalian neuroendocrine system. Oestrogen and oestrogen receptors play a key role in mammalian physiology. Endocrine disruptors, such as ZEA have the ability to interfere with hormonal regulatory pathways due to their oestrogenlike molecular structure. The aim of the present review is to discuss the best known effects of ZEA poisoning. ZEA is a well-known mycotoxin, usually found in contaminated unprocessed maize and other cereal kernel. The contamination begins at the growing area, however it can also spread during improper storage, causing a contamination in the feed. This is still a serious problem in animal husbandry and in the industrial production of meat. After ingestion, the toxin can easily get into the body. ZEA can directly induce apoptosis, thus causing cell loss in specific organs (mostly in the liver and the immune system) resulting in a decreased, weakened function. In addition to the cellular effects, ZEA also acts as endocrine disruptor, it alters the physiological neuroendocrine regulation, thus disrupting the physiological action of the organs requiring oestrogen modulation. ZEA has a serious impact on the production of the cellular components of the blood; the quality, and cellular quantity of the immune response; the homeostasis and the functions during detoxification of the liver and kidneys; the neuroendocrine organ functions (disrupting the regulative characteristics of specific parts of the hormonal milieu in the animals) and even on the central nervous system. Most importantly ZEA can interfere with the reproductive physiology of animals (due to the disruption on the neuroendocrine regulation), thus lowering the possible productivity of the livestock, causing major economic losses.en_US
dc.language.isohuen_US
dc.publisherMagyar Állatorvosok Lapjaen_US
dc.titleA zearalenon mint mikotoxin káros hatásai az emlős szervezetben: az utóbbi évtizedek eredményeinek rövid áttekintéseen_US
dc.title.alternativeAdverse biological effects of the mycotoxin zearalenone in mammals: a reviewen_US
dc.typeArticleen_US
dcterms.bibliographicCitationMagyar Állatorvosok Lapja 139(1), 55-63. (2017)


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