Rövid rekord

dc.contributor.authorMelia, Graham
dc.date.accessioned2015-02-11T12:56:28Z
dc.date.available2015-02-11T12:56:28Z
dc.date.issued2014
dc.identifier.otherB-10990
dc.identifier.urihttp://hdl.handle.net/10832/1234
dc.description.abstractΒ-defensins are widely expressed and rapidly induced at epithelial surfaces to defend against diverse microorganisms such as bacteria, viruses, fungi and parasites. These innate effector molecules are conserved across a wide range of species. It has been shown that their function extends further than antimicrobial action. They have been shown to act as chemokines, induce cytokines, control dog coat colour and facilitate reproduction in the rhesus macaque. Here I show that the cluster of β- defensisns on chromosome 13 in Bos taurus has homologues in human, chimp, macaque, rat, mouse and horse. These homologues are novel in the equine genome. I also show that the positions of these defensins are conserved across mammalian species, except in human and chimp where a chromosome inversion is observed. Expression of selected defensins is characterised in the male and female bovine reproductive tract and found to be restricted to the testis, tail of the epididymis, vas deferens, tail of the Fallopian tube and uterus. From these results I conclude that the function of β-defensins in the bovine reproductive tract could be to facilitate reproduction as well as protect the reproductive tract from infection.en
dc.language.isoenen
dc.subjectszarvasmarhaen
dc.subjectdairy cowen
dc.subjectnőivarú állaten
dc.subjectfemale animalen
dc.subjecthímivarú állaten
dc.subjectmale animalen
dc.subjectnemi szerveken
dc.subjectgenitalsen
dc.subjectpeptideken
dc.subjectpeptidesen
dc.subjectimmunrendszeren
dc.subjectimmune systemen
dc.subjectdiagnosztikaen
dc.subjectdiagnosticen
dc.subjectmolekuláris próbaen
dc.subjectmolecular probeen
dc.titleMolecular and expression study of the gene beta-defensin in male and female bovine reproductive tracten
dc.typeThesisen


A tételhez tartozó fájlok

Thumbnail

Ez a dokumentum a következő gyűjtemény(ek)hez tartozik:

Rövid rekord