HuVetA

A HuVetA Magyar Állatorvos-tudományi Archívum az Állatorvostudományi Egyetem adattára. Célja, hogy a magyar állatorvos-tudomány és -történet dokumentumait, tudásvagyonát elektronikus formában összegyűjtse, rendszerezze, megőrizze, kereshetővé és hozzáférhetővé tegye.

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Állatorvostudományi Egyetem / University of Veterinary Medicine Budapest
This is a collection of documents from University of Veterinary Medicine Budapest
Diplomadolgozatok / Theses
Doktori Iskola / Doctoral (Phd) School
ICAHIS
Fulltext and abstracts of the 9th ICAHIS conference.
Magyar Állatorvosok Lapja
Magyar Állatorvosok Lapja is the only peer-reviewed journal in Hungarian that publishes high-quality veterinary research.
Publications
This is a collection of publications from University of Veterinary Medicine.
Történeti anyagok és emlékek / Historical Documents
Video archive

Recent Submissions

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Nagy széltippant (Apera spica-venti) tartalmazó széna fogyasztásával összefüggő szájüregi elváltozások egy lóállományban

(2026-10) Cserhalmi, Dániel; Laky, Enikő; Péli, Evelin Ramóna

ÖSSZEFOGLALÓ A szerzők közleményükben bemutatják, hogy egy Nógrád vármegyei lovarda 14 lovából 11 esetében alakultak ki szájüregi nyálkahártya-elváltozások, fokozott nyálzás és egyes esetekben hasmenés új széna etetését követően. A botanikai vizsgálatok a szénában és a szájüregből vett mintákban nagy széltippan (Apera spica-venti) jelenlétét igazolták. A tüneteket valószínűleg a növény érdes szálkái által okozott mechanikai irritáció idézte elő. A takarmány cseréjét követően specifikus kezelés nélkül valamennyi állat meggyógyult. Az eset rámutat a széna botanikai összetételének vizsgálatában rejlő megelőzési lehetőségekre. SUMMARY Oral lesions caused by toxic plants are well documented in horses; however, less attention has been paid to mechanical injuries associated with the consumption of contaminated hay. In March 2025, oral mucosal lesions were observed in 11 of 14 horses housed in a riding stable in Nógrád County, Hungary. Clinical signs developed shortly after the introduction of a new batch of hay and included excessive salivation, gingival and oral mucosal inflammation, and, in the most severe cases, ulcerative lesions. Mild diarrhea was also observed in some affected animals. No abnormalities were detected in the general clinical parameters. Samples were collected from the oral cavities of the affected horses and from the hay suspected to be associated with the outbreak. Botanical analyses were performed at the Department of Botany of the University of Veterinary Medicine Budapest. The presence of loose silky-bent (Apera spica-venti) was confirmed both in the hay samples and in the material collected from the oral cavity. Hairy calyces of crimson clover (Trifolium incarnatum) were also identified, although no other potentially toxic plant species were detected. Quantitative analysis of the botanical composition was not performed. Clinical observations suggested that the lesions were caused by mechanical irritation of the oral mucosa by the rough awns and other epidermal structures of A. spica-venti. Following the immediate removal of the hay and its replacement with hay free of the species, the clinical signs gradually resolved without specific treatment. Diarrhea disappeared within three days, while oral lesions healed within one to two weeks depending on their severity. This case highlights the importance of considering mechanically irritating plant species as a cause of oral disease in horses. The findings also emphasize the value of botanical examination of hay before feeding, as routine assessment of species composition may contribute to the prevention of forage-related health disorders and improve equine welfare.

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Lokivetmab (Cytopoint®) – célzott IL-31-gátlás kutyák prurituszában: bizonyítékok és gyakorlati tanulságok

(2026-10) Tóth, Zsombor Tamás; Tarpataki, Noémi

ÖSSZEFOGLALÁS A szerzők az eddig megjelent irodalmi adatok alapján áttekintik a lokivetmab, a kaninizált IL-31 monoklonális ellenanyaggal kapcsolatos tudnivalókat, különös tekintettel a kutyák atópiás dermatitiszéhez (cAD) társuló viszketésre. Részletesen ismertetik a cAD kórélettanát, különös tekintettel a pruritusz neuroimmunológiájára. A rendelkezésre álló vizsgálatok eredményei a lokivetmab gyors és hatékony viszketéscsillapító hatásáról számolnak be. A megfigyelések szerint a kedvező hatás többnyire fenntartható, ugyanakkor egyéni válaszkülönbség és ritka hatásgyengülés előfordul. A biztonságossági vizsgálatok kedvező profilt és gyenge immunogenitást mutatnak. A cAD multimodális terápiájába illeszthetőségét bizonyítja, hogy egyéb terápiás szerekkel (bőrbarrier-támogatás, allergénspecifikus immunterápia) további klinikai javulás érhető el. SUMMARY This narrative review summarises the clinical evidence for lokivetmab (Cytopoint®), a caninised monoclonal antibody that neutralises interleukin-31 (IL-31), a key neuroimmune pruritogenic cytokine in canine atopic dermatitis (cAD) and other allergic dermatoses. Randomised, masked field trials consistently demonstrate rapid, clinically meaningful reductions in owner-assessed pruritus compared with placebo, with benefits that can persist for weeks after a single injection. Lesion indices and global assessments generally improve as well, but often more gradually and with greater inter-individual variability, reflecting the multipolar, phase-dependent inflammation of cAD and the contribution of secondary infections and barrier dysfunction. Real-world cohorts confirm high response rates and sustained benefit in most dogs, while documenting occasional par- tial response or loss of effect over time; in practice this is frequently linked to uncontrolled comorbidities such as otitis externa, pyoderma or Malassezia spp. overgrowth, seasonal allergen pressure, or inadequate trigger control. Studies exploring expanded outcomes suggest that targeted IL-31 blockade may also improve patient comfort, sleep and owner-perceived quality of life, and may support proactive maintenance strategies aimed at reducing flare frequency. Combination approaches—particularly structured topical therapy, management of microbial dysbiosis, and use as stabilising treatment while longer-acting causal interventions mature—appear clinically useful. Available safety data indicate favourable tolerability with low immunogenicity and no signal of classical immunosuppression. Overall, lokivetmab is a well-supported option for targeted itch control, best applied within a multimodal plan addressing infection, ears, skin care and allergen exposure.

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A propolisz lehetséges szerepe kutyák bőrgyógyászati és egyéb kórképeinek kiegészítő terápiájában : Irodalmi áttekintés

(2026-10) Tóth, Zsombor Tamás; Tarpataki, Noémi Katalin; Nemes-Terényi, Melinda; Jerzsele, Ákos; Kerek, Ádám

ÖSSZEFOGLALÁS A szerzők célja a propolisz kutyákban való alkalmazási lehetőségeinek áttekintése, különös tekintettel a bőrgyógyászati jelentőségű helyi indikációkra, de kitérve egyéb klinikai és transzlációs területekre is. Célzott irodalomkereséssel értékelték a kutyákon végzett in vivo, valamint kutyaeredetű izolátumokon és sejtvonalakon végzett in vitro vizsgálatokat. A legerősebb bizonyíték a sebgyógyulás, a Staphylococcus spp. és Malassezia pachydermatis elleni aktivitás, valamint egyes szemészeti kiegészítő alkalmazások mellett szól. A bizonyítékok ugyanakkor heterogének, a készítmények összetétele és kivonási módja jelentősen eltér, ezért a propolisz jelenleg elsősorban kiegészítő lokális terápiás lehetőségként értelmezhető. SUMMARY Propolis has attracted increasing interest in small-animal medicine as a natural product with antimicrobial, anti-inflammatory, antioxidant, wound-healing and biofilm-modulating properties. The aim of this review was to critically summarize the available evidence in dogs, with particular emphasis on clinically relevant local applications. A targeted literature search was performed in major international and Hungarian databases, and publications were included if propolis or propolis extracts had been used in vivo in dogs or had been tested in vitro on canine clinical isolates or canine-derived cell systems. The final qualitative synthesis included 24 publications covering wound healing, superficial staphylococcal pyoderma, Malassezia-associated otitis or dermatitis, ophthalmic adjunctive therapy, and several more distant translational fields such as dentistry, implantology, oncology, immunology and virology. The most practice-oriented evidence supports a potential adjunctive role in wound management, against Staphylococcus spp. and Malassezia pachydermatis, and in selected ophthalmic settings. However, the overall evidence base remains fragmented: study designs are heterogeneous, sample sizes are often small, endpoints are not standardized, and the tested products vary markedly with respect to botanical origin, extraction solvent and formulation. Safety and standardization remain central translational concerns. Consequently, current data do not justify routine stand-alone use of propolis in canine practice. At present, propolis should be interpreted primarily as a promising adjunctive local option whose place in therapy must be defined by standardized preparations, well-designed controlled clinical studies and clinically comparable outcome measures.

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Újdonságok az állatorvosi epilepsziában – 2025 „A tavalyi év kutatási eredményeit már ma alkalmazzuk a napi praxisban!“ : Irodalmi összefoglaló

(2026-10) Pákozdy, Ákos

ÖSSZEFOGLALÁS A szerző jelen cikkében bemutatja a 2025-ben megjelent nemzetközi tudományos közlemények közül azokat, amelyek ismeretét a témában legfontosabbnak tartja a praxisban dologozó kollégák részére. Ezek a következő szalagcímekben foglalhatóak össze: az ammóniaszint emelkedett lehet kutyában és macskában közvetlenül konvulzív epilepsziás rohamok után, portoszisztémás sönt vagy egyéb májbetegség hiányában is. Transcranialis mágneses stimulációs kezelés segíthet csökkenteni epilepsziás kutyák rohamait. A cannabidiol kezelés jó kiegészítője lehet a szokásos gyógyszeres terápiának. A brachycephal kutyák gyakrabban mutatnak strukturális agyi léziókat, mint hasonló korú, nem brachycephal fajtársaik. Bíztató eredményeket közöltek a macskák hyperaesthesiás szindrómájának kezeléséről. SUMMARY In this annual mini-review, the most relevant research findings in the field of clinical epilepsy in dogs and cats are presented. The author selected and summarized several significant results from the international literature published in 2025. The following key topics are discussed: (i) Elevated ammonia levels can be detected not only in liver diseases and portosystemic shunts, but also following convulsive epileptic seizures. In one study, ten dogs exhibited increased serum ammonia levels temporarily after epileptic motor seizures, without evidence of underlying liver disease. However, this phenomenon is not entirely novel, as similar cases have previously been reported in cats. (ii) A non-invasive transcranial magnetic stimulation therapy trial demonstrated promising results in dogs with therapy-resistant epilepsy in a German study. (iii) The effects of cannabidiol supplementation in dogs with severe epilepsy were also analyzed. Beneficial outcomes were observed, as the frequency of seizures decreased following administration of cannabidiol at appropriate doses. Furthermore, positive behavioral effects were reported, with several owners noting that their dogs were less sedated, more active, and exhibited an improved quality of life. (iv) Another study identified a potential association between epilepsy and brachycephaly in dogs. In these breeds, glial neoplasms appear to be more frequent than in non-brachycephalic breeds. (v) A challenging clinical condition was successfully managed in cats: feline hyperesthesia syndrome was effectively controlled longterm, primarily with the selective serotonin reuptake inhibitor fluoxetine. However, adjunctive therapy, including behavioral modification and gabapentin, was also applied. The author hopes that this work may facilitate the implementation of research findings into daily Hungarian clinical practice and that the new knowledge published in 2025 may be directly beneficial for canine and feline patients soon.

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Vadmadár-adenovírusok genetikai diverzitása, evolúciója, patogenitása és diagnosztikája

(2026-10) Máté, Lilla Katalin; Harrach, Balázs; Kaján, Győző László

ÖSSZEFOGLALÁS A szerzők közleményükben áttekintik az Adenoviridae család madarakat fertőző tagjainak főbb jellemzőit, amelyek három nemzetségbe sorolható, burokkal nem rendelkező, lineáris, kétszálú DNS-t tartalmazó vírusok. Bemutatják, hogy e vírusok általában szűk gazdaspektrummal rendelkeznek, és fertőzésük többnyire tünetmentes, ugyanakkor egyes esetekben – különösen fiatal egyedekben – súlyos kórképek kialakulásához is vezethet. Kiemelik a gazdaszervezettel fennálló koevolúciós kapcsolat patogenitást meghatározó szerepét, valamint azt, hogy a diagnosztikában napjainkban elsősorban molekuláris módszereket alkalmaznak. A szerzők rámutatnak arra is, hogy a madár-adenovírusok genetikai diverzitása és evolúciós folyamatai továbbra sem teljeskörűen feltártak. A gazdaváltás és a környezeti változások ugyanakkor növelhetik e vírusok járványtani jelentőségét, ami indokolja folyamatos monitorozásukat. SUMMARY The authors provide an overview of the principal characteristics of avian viruses belonging to the family Adenoviridae, which comprises non-enveloped, linear double-stranded DNA viruses classified into three genera. They describe how these viruses generally exhibit a narrow host range and that infections are often asymptomatic, although severe clinical disease may develop in certain cases, particularly in young birds. The authors highlight the important role of co-evolutionary relationships with the host in determining viral pathogenicity and note that molecular methods currently predominate in the diagnosis of avian adenovirus infections. They further point out that the genetic diversity and evolutionary dynamics of avian adenoviruses remain incompletely understood. Host switching and environmental changes may, however, increase the epidemiological significance of these viruses, underscoring the need for their continued surveillance.

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A Pasteurella multocida genetikai változatossága, a gazdaadaptáció jelei és az antibiotikum rezisztencia terjedése

(2026) Lipcseiné dr. Pintér, Krisztina

Pasteurella multocida is a globally distributed, Gram-negative bacterial species with zoonotic potential, that has significant economic and public health impacts. Strains of this species show a high genotypic and phenotypic heterogeneity, which contributes to the development of diverse diseases based on different pathomechanism affecting different host species. These infections are typically treated with antibiotics, however, the increasing emergence and spread of multidrug-resistant (MDR) strains is a challenge of increasing importance to both veterinary and human healthcare. Detailed molecular characterization of these strains, along with a deeper understanding of their antibiotic resistance is vital to elucidate the pathogenesis and epidemiological dynamics of infections, to develop effective therapeutic strategies and to mitigate zoonotic risks. Collectively, these insights will facilitate the development of targeted prevention and treatment protocols. The aim of this study was the detailed pheno- and genotypic characterization of P. multocida strains. We aimed to explore and statistically analyse the associations between virulence gene profiles (VGPs), clusters established on the basis of ompA gene sequences, and other characteristics of the strains – including serotype, Multi-host (MH) and the Rural Industries Research and Development Corporation (RIRDC) sequence type (ST), and host origin. Another objective was to assess the antibiotic susceptibility profiles of Hungarian and French P. multocida strains using both phenotypic (disk diffusion, broth microdilution) and genotypic (whole-genome sequencing) approaches. In this study, the antibiotic susceptibility of 80 P. multocida isolates of Hungarian and French origin, collected from various host species between 2004 and 2023, was examined. Particular attention was given to the occurrence of MDR strains, and the heterogeneity of the sample set enabled the identification of resistance-related trends. The strains were tested against antibiotics from ten antibiotic classes: penicillins, cephalosporins, aminoglycosides, tetracyclines, macrolides, fluoroquinolones, lincosamides, phenicols, polymixins and sulfonamides. Antibiotic resistance genes (ARGs) and single-nucleotide polymorphisms (SNPs) were identified using Bacterial and Viral Bioinformatics Resource Center (BV-BRC) and the Comprehensive Antibiotic Resistance Database (CARD) Resistance Gene Identifier (RGI) tool. Plasmid carriage in MDR strains was examined using the Solu server. To increase the reliability of the statistical analyses, detailed genotypic characterization was also performed for an additional 50 P. multocida genomes available in the National Center for Biotechnology Information (NCBI) database. Strain sequences were aligned to different reference genomes, allowing characterization of virulence gene carriage, and further VGP groups were separated. Capsule type and lipopolysaccharide (LPS) genotype were identified using a Danish bioinformatics server, while MH- and 8 RIRDC-STs were determined via the Public databases for molecular typing and microbial genome diversity (PubMLST) database. A phylogenetic tree based on ompA gene sequences revealed twenty-five wellseparated clusters. Based on the analysed virulence gene patterns, fourteen new VGP profiles were identified, thus currently twenty-seven VGP groups are known. The most common capsule-LPS genotype combination (serotype) was A:L3 (n=46), followed by A:L1 (n=23) and F:L3 (n=18). Some strains carried multiple point mutations in the tadD primerbinding region, resulting false-negative polymerase chain reactions (PCR). To overcome this, new primers were design based on whole-genome sequences, enabling reliable diagnostic identification of the gene. Phenotypic antibiotic susceptibility testing indicated that cephalosporins and phenicols were the most effective agents for treating P. multocida infections. In addition, it was observed that the majority of strains showed high susceptibility to fluoroquinolones and tetracyclines. In contrast, high resistance rates were observed against sulfamethoxazole and clindamycin. The most frequently identified resistance genes were strA (n=7), sul2, and tetH (n=6), while none of the strains carried the bla-TEM or erm(42) genes. Based on whole-genome sequencing data and plasmid carriage analysis, none of the isolates harboured integrative-conjugative elements (ICE). Significant associations were observed between the VGP groups of strains, the ompA clusters, and some other characteristics of the isolate, primarily host species, serotype, and sequence type. These relationships contribute to a deeper understanding of the pathogenesis and epidemiological dynamics of the diseases caused by P. multocida. Comparison of the results of antibiotic susceptibility tests revealed consistency between phenotypic susceptibility and the presence of resistance genes in most cases. However, in the case of certain antibiotic classes – sulfonamides, macrolides, and β- lactams – there were discrepancies between the genotypic and phenotypic results. In these cases, the genetic background of the phenotypically observed resistance could not be clearly identified, suggesting that, in addition to the currently known mechanisms, other, as yet undiscovered factors may also play a role in the development and maintenance of resistance

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Comparative Veterinary Pharmacokinetics and Drug Metabolism

(University of Veterinary Medicine Budapest, 2024) Csikó György

Foreword Pharmacokinetics involves all aspects of the absorption, distribution, metabolism, and excretion of drugs that are necessary for tracking the fate of a drug within the body and hold significance in drug therapy. The aim of this book is to provide a detailed presentation of both conventional and the latest scientific knowledge in veterinary pharmacokinetics. When applying drugs, it is essential to consider all factors that may influence their efficacy and safety. Animal species differ significantly in terms of anatomy and physiology. Additionally, pharmacokinetic properties of drugs can be significantly affected by breed, individual genetic differences, sex, age, health status and diet. This book explores the effects of these and other factors on pharmacokinetic processes. Understanding these factors enables more effective and safer use of medications. Another important goal of presenting this knowledge is to promote the production of residue-free animal-derived food products and to reduce the development of antimicrobial resistance through even more professional drug use. Possessing appropriate and detailed pharmacokinetic knowledge also enhances the efficiency of experimental research, which, beyond achieving more accurate results, is also of paramount importance from an animal welfare perspective. This book will be valuable to professionals working in research or practical fields, both within Hungary and in Hungarian-speaking communities abroad, such as veterinarians, animal breeders, research physicians, pharmacists, and biologists. Furthermore, it provides assistance to university lecturers and supports the preparation of university students (involved in veterinary medicine, pharmacy or biology). The author of this book has been engaged in teaching and research activities in this field for over three and a half decades. He is also the author and co-editor of several related academic articles, university lecture notes, and professional books. In the field of veterinary pharmacokinetics, he has accumulated significant knowledge derived from his own research and literature sources, which he aims to publish in this book.