| dc.description.abstract | The brain-specific protein, Seizure‐related gene‐6 (Sez-6), plays an important role in
the development of appropriate neuronal circuitry in the mammalian central nervous system.
Especially, Sez-6 is an essential regulator of dendritic branching, dendritic spine formation
and excitatory synapse numbers.
In this manner Sez-6 -/- animals have been shown to possess morphologically different
neurons and dendritic arborization. Indeed, Sez-6 -/- mice exhibit an excess of short dendrites,
an excessive neurite branching and a reduced spine density relative to WT neurons. Similarly,
a greater proportion of spines were observed on dendrites of control cortical neurons than on
Sez-6 -/- neurons. | en_US |
