| dc.description.abstract | In-vivo studies with animal models have been crucial in understanding the prediction
pathway and effects of inhaled aerosol particles. Rodents are used to represent the human
respiratory tract, however, there are distinct differences in anatomy and physiology, which
affect airflow and particle deposition. By studying anatomically realistic 3D models of both
rat and human nasal cavities, physical parameters, such as internal dimensions can be
measured, and the particle deposition of different-sized particles can be studied. Micronsized particles are classified into low, medium, and high inertial particles based on the total
deposition, sized 1, 2, and 3 µm for the rat and 2.5, 9, and 20 µm for the human model. | en_US |
