| dc.description.abstract | Persistent organic pollutants (POPs) make up a substantial portion of the ocean’s contaminants.
While their acute, high-concentration encounters are mostly lethal, their chronic consequences
show more complex pathogenesis. These pathogenic pathways are suspected of having both
direct and indirect POP aetiology.
Direct mutagenic effects through Aryl hydrocarbon Receptor (AhR) activation, DNA adduction
or in utero foetal maldifferentiation have been associated with long-term POP accumulation in
terrestrial mammals, marine mammals, and humans. Indirect effects through the CYP-enzyme
biotransformation and MFO system are not fully understood yet. | en_US |
