| dc.description.abstract | The gastrointestinal tract has a large surface area in contact with harmful agents
that enter the body through the oral route, and through its complex function,
it plays a significant role in keeping pathogenic microorganisms and other
hazardous compounds away. Almost every fifth dog is affected by some form of
enteropathies. Intestinal diseases can be divided into acute and chronic forms.
In order to establish the exact diagnosis, various additional tests, including
faecal examination, abdominal ultrasound, gastroscopy, and histopathological
examination may be indispensable. Often not only the diagnosis, but also
the treatment is very complex and complicated. The use of in vitro models is
essential for a more precise understanding of the cause of inflammatory bowel
diseases and for examining its therapeutic possibilities. Several in vitro models
have become widely used to study intestinal diseases in dogs. In addition to
the homogeneous two-dimensional sustainable cell lines of tumour origin, such
as the Caco-2 and HT-29 colon carcinoma cell lines, which are very popular for
permeability studies, three-dimensional organoid cultures with a heterogeneous
cell composition have also appeared, which allow improved modelling of in vivo
conditions. From the results of in vitro intestinal research studies in dogs, root
causes of diseases can be better understood, and new therapeutic options can
be revealed, which can ensure more successful treatment and a better quality
of life for our canine patients. From the results, relevant conclusions can be
drawn for human medicine, based on the similarity of the environment and
nutrition of dogs and humans, of the structure of the intestinal system, and the
composition of the microbiota, and of intestinal diseases. | en_US |
