| dc.description.abstract | Like human inflammatory bowel disease, canine chronic enteropathies are not
a fully understood disease group. Accurate knowledge of the cytokines involved
in the inflammatory response can be invaluable in both diagnosis and therapy.
In human gastroenterology, considerable attention has been paid to their investigation, but in the veterinary field, there are few clear results so far. The authors
describe the immunological background of chronic enteritis that has been mapped so far, mainly in terms of cytokine expression, and summarise the results of
studies to date on cytokines specific for similar diseases in dogs. Cytokines are
polypeptide hormone-like molecules that enable communication between cells
and can foster or limit inflammatory processes. The pathophysiology of chronic
inflammatory enteropathy (CIE) in dogs is still only partially delineated, but its
understanding could lead to significant advances in the clinical approach to
this patient population. Based on the results of studies carried out in the past
decades in this area, TNFα, IL1β, IL12, IL23 and IL33 might be of higher importance
in initiating inflammation in the bowel and these might have a potential to be
used as biomarkers or therapeutic targets in CIE. | en_US |
