| dc.description.abstract | Feline idiopathic cystitis (FIC) is one of the most common disorders in feline veterinary
praxis with different combinations of symptoms such as hematuria, stranguria, dysuria,
periuria, pain and hypersensitivity during urination. In case of the occurrence of petechial
hemorrhages of bladder submucosa of symptomatic cats detectable by cystoscopy, the
disease is referred as interstitial cystitis. This name also reflects the similarities in symptoms
and pathogenesis to human interstitial cystitis (IC). The exact cause and pathogenesis of the
disease are widely studied; however not yet fully understood. FIC is considered as a
multifactorial disease, based on a complex interaction between the urinary bladder, adrenal
glands, nervous- and immune system and the environment. It is strongly suggested that
stress may have an important role in the history of FIC, so the examination of this factor is
essential to have a more accurate understanding of the development of the disease.
Therefore, the first main goal of the present thesis was to establish a novel, wellcharacterized primary uroepithelial cell culture from feline origin which contains differentiated
urothelial cells and could serve as a proper tool for studying the biochemical background of
FIC in vitro, especially focusing on the pathological role of the main regulatory stress
hormone norepinephrine (NE) in the pathomechanism of FIC. | en_US |
