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dc.contributor.authorGál, Bence
dc.contributor.authorVarga-Kugler, Renáta
dc.contributor.authorIhász, Katalin
dc.contributor.authorKaszab, Eszter
dc.contributor.authorDomán, Marianna
dc.contributor.authorFarkas, Szilvia
dc.contributor.authorBányai, Krisztián
dc.date.accessioned2024-09-23T10:09:37Z
dc.date.available2024-09-23T10:09:37Z
dc.date.issued2023
dc.identifier.citationGál B, Varga-Kugler R, Ihász K, Kaszab E, Domán M, Farkas S, Bányai K. Marked Genotype Diversity among Reoviruses Isolated from Chicken in Selected East-Central European Countries. Animals (Basel). 2023 Jun 28;13(13):2137. doi: 10.3390/ani13132137en_US
dc.identifier.urihttp://hdl.handle.net/10832/4076
dc.description.abstractThe concern that the vaccines currently used against Avian orthoreovirus (ARV) infections are less efficient in the field justifies the need for the close monitoring of circulating ARV strains. In this study, we collected necropsy samples from various chicken breeds and tested for ARV by virus isolation, RT-PCR assay and sequence analysis. ARVs were isolated from birds showing runting-stunting syndrome, uneven growth, lameness or increased mortality, with relative detection rates of 38%, 35%, 6% and 25%, respectively. Partial σC gene sequences were determined for nearly 90% of ARV isolates. The isolates could be classified into one of the major genetic clusters. Interestingly, cluster 2 and cluster 5 were isolated from vaccinated broiler breeders, while clusters 1 to 4 were isolated from unvaccinated broilers. The isolates shared less than 75% amino acid identities with the vaccine strains (range, 44.3-74.6%). This study reaffirms the global distribution of the major genetic clusters of ARVs in chicken. The diversity of ARV strains isolated from unvaccinated broilers was greater than those detected from vaccinated animals, however, the relative importance of passive and active immunity on the selection of novel strains in different chicken breeds needs to be better understood.en_US
dc.language.isoenen_US
dc.titleMarked Genotype Diversity among Reoviruses Isolated from Chicken in Selected East-Central European Countriesen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ani13132137


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