| dc.description.abstract | ÖSSZEFOGLALÁS
Humán vizsgálatok és elsősorban egerekkel és patkányokkal végzett állatkísérletek
alapján a cukorbetegség kiegészítő terápiájában sikeresen alkalmazhatók egyes
nyomelemek (króm és vanádium), mikroelemek (cink és szelén), makroelemek
(magnézium), vitaminok (elsősorban az antioxidáns hatásúak, pl.: C- és E-vitamin) és antioxidánsok (pl.: Q10 koenzim, alfa-liponsav) is. A szerzők szakirodalmi
összefoglalójukban ismertetik ezek hatásmechanizmusát különös tekintettel
gyakorlati alkalmazásukra kutyák és macskák esetében.
SUMMARY
Diabetes mellitus is one of the major health problems in dogs and cats. Type 1
diabetes (insulin-dependent) is rare in cats, while type 2 (non-insulin-dependent)
– associated with obesity – has a growing importance. Approximately 80–90%
of diabetic cats have type 2 diabetes. Contrary to this in dogs, type 1 diabetes
is common while obesity-induced insulin resistance does not progress to type
2 diabetes.
Deficiencies in minerals, trace elements, vitamins and antioxidants are related
to widespread health problems, including diabetes. According to several human
and animal studies, an extra supply of some of these nutrients can improve the
health of diabetic patients. It may also reduce the risk of diabetic complications.
This review aims to summarise the most important dietary supplements, emphasizing their application in dogs and cats.
Chromium intracellularly binds to an oligopeptide apochromodulin which makes
the active chromodulin. Then chromodulin binds to the inner part of the insulin
receptor and fully activates it. In diabetic dogs, 100 μg/day of chromium yeast may
reduce blood sugar. In healthy cats, 600 ppb of chromium picolinate decreased
the fasting blood sugar level. Vanadium can lower elevated blood glucose, cholesterol, and triglycerides. Natrium metavanadate (0.1-0.2 mg/ml in drinking water)
decreased fasting glucose, fructosamine, and cholesterol levels of alloxan-induced
diabetic dogs, but the side effects of the treatment were severe. The combination of vitamin E, vitamin C, and selenium decreased the blood sugar level and
increased the antioxidant enzyme (superoxide dismutase, catalse) concentration
of diabetic dogs.
Several human and animal studies also described the potentially positive effects
of magnesium, selenium, zinc, alpha-lipoic acid, and coenzyme-Q10. More dog
and cat studies are needed to examine the physiological effects of these supplements on diabetic animals. | en_US |
