| dc.description.abstract | Fragile Foal Syndrome (FFS) is a fatal autosomal recessive inherited disorder
initially seen in some warmblood horses, but since has been identified in
other breeds such as Thoroughbreds. It is a point mutation in the PLOD1
gene, which is responsible for both collagen production as well as
maintaining the integrity of connective tissue. This mutation results in the
interference of the collagen synthesis, resulting in deadly physical
deformities, such as hyperextensible skin and hypermobile joints, which
results in death within hours. | en_US |
