| dc.description.abstract | ÖSSZEFOGLALÁS
A lovak korszerű parazitaellenes kezelésének alapjait a szerzők egy 2021-ben publikált közleményben mutatták be. Jelen összefoglalóban ismertetik a féregellenes
készítmények hatékonyságának vizsgálatához szükséges irányelveket. Bemutatják
az alkalmazott módszereket, beleértve a bélsárpeteszám-csökkenési tesztet, a
peték újramegjelenési idejének meghatározását, valamint a lárvális stádiumok
elleni hatékonyság értékelését. Szemléltetik, hogy a bevont állatok és az egyes
belső élősködők esetében a vizsgálat megtervezése során milyen szempontokat
kell figyelembe venni. Ezenkívül összegzik a gyógyszer-rezisztenciával kapcsolatos
legfrissebb ismereteket is.
SUMMARY
In our previous report from 2021, we sought to provide the necessary information
for implementing parasite control programs for horses, based on both Hungarian
and international literature. The primary objective of parasite control in equines is
to maintain the health of the animals and reduce the risk of clinical illness rather
than to eradicate all parasites from an individual horse. Eradication is not only
unattainable but also accelerates the development of drug-resistant parasites.
Therefore, the principal aims of any parasite control program are to minimise the
risk of parasitic disease, delay the further development of anthelmintic resistance,
and preserve the efficacy of these drugs for as long as possible. While resistance
is consistently observed in managed horses globally, significant variations exist
between individual farms. Resistance cannot be confirmed on any specific farm
without proper testing. In this literature review, our goal was to summarise the
guidelines for evaluating the efficacy of equine anthelmintics. These guidelines assist in the design, execution, and interpretation of studies that assess
the effectiveness of anthelmintic drugs against internal parasites in equines,
including nematodes, cestodes, and the larval stages of Gasterophilus spp. This
document provides comprehensive guidance relevant to domestic equines and is
intended to support researchers and field practitioners in designing scientifically
robust studies to evaluate the efficacy of new or existing anthelmintic drugs.
Additionally, it offers criteria for determining the appropriate size of test animal
groups in terminal studies to ensure sufficient statistical power for detecting the
expected magnitude of the effect. The guidelines summarise standard methods
for evaluating anthelmintic efficacy in equines and outline the relevant biological
and technical considerations specific to each parasite category. | en_US |
