| dc.description.abstract | ÖSSZEFOGLALÁS
Jelen tanulmányban a szerzők a doxiciklin és moxidektin kombinációs terápia hatékonyságát vizsgálták magyarországi kutyák szívférgességének (Dirofilaria immitis) kezelésére.
A terápiás protokoll során az állatok az első 30 napban doxiciklintartalmú tablettát
kaptak szájon át, emellett havonta, legfeljebb 2 éven keresztül, moxidektintartalmú
rácsepegtető oldatos kezelésben is részesültek. A kezelés sikerességének ellenőrzésére
3 havonta módosított Knott-tesztet, valamint két különböző gyártótól származó antigéngyorstesztet végeztek el vérmintákból. Az eredmények azt mutatják, hogy a 12. hónapra
a vizsgálatba bevont, minden fertőzött állatból származó minta vizsgálati eredményei
negatívnak bizonyultak D. immitis okozta fertőzöttségre nézve.
SUMMARY
Background: The spread of Dirofilaria immitis is a global issue nowadays.
Recommended treatment of heartworm infestation is difficult, complex and
expensive, and can even have severe adverse effects. For those cases when using
melarsomine dihydrochloride is contraindicated because of the animals’ condition, or
when the owner rejects the recommended treatment protocol, other effective and safe
treatment alternatives should be advised, like doxycycline and moxidectin combination
treatment.
Objectives: The aim of the study was to evaluate the efficacy of a doxycycline and moxidectin combination treatment protocol in confirmed D. immitis infested dogs in Hungary.
Materials and Methods: During the two years study period 86 naturally infected dogs
were involved in the study that met the eligibility criteria ((i) confirmed infestation with
D. immitis, (ii) having mild or moderate clinical signs, and (iii) therapy with melarsomine
was rejected by owner). In the first 30 days doxycycline tablet was given orally to the
animals (6-10 mg/kg twice daily (BID)). Beside doxycycline, moxidectin spot on (2.5 mg/
kg) was administered externally every month for two years. To assess the efficacy of
the treatment protocol, blood samples were taken (in EDTA tubes) from the dogs every
third month. Modified Knott test, and two antigen tests (Witness Dirofilaria test, Zoetis;
Bionote Canine Heartworm test, Bionote) were performed from the samples. Dogs were
considered cured if all tests were negative in two consecutive time points.
Results and Discussion: From the study population, as a result of the treatment
9 dogs were considered cured by the sixth month, further 50 were cured by the ninth
month, further 21 were cured by the twelfth month and the last animal was cured by
the fifteenth month. Four animals had to be excluded from the study because of not
showing up on the appointment, and one dog died because of reasons not related to
heartworm disease. There was no animal with persistent D. immitis infestation, therefore
the doxycycline and moxidectin treatment protocol was considered to be an effective
alternative option for certain heartworm cases. | en_US |
