Measurement of the gene expression rate of certain p53 family genes in experimental animals after metal oxide fume inhalation.

Abstract

The p53 protein family is pivotal in preventing tumoral cell transformations by aiding DNA repair or inducing apoptosis in cases of irreparable damage. This mechanism activates not only for tumor prevention but also for various DNA damages, such as those caused by oxidative stress from inhalation of Zn or Cu oxides. These oxides can induce metal fume fever (MFF), an occupational ailment primarily affecting welders and metal workers, potentially leading to chronic asthma.