Luteolin and chrysin could prevent lipopolysaccharideochratoxin combination-caused inflammation and oxidative stress in vitro

Abstract

Ochratoxin A (OTA) produced by Aspergillus and Penicillium spp. can contaminate cereal-based foods and feedstuffs and their oral consumption can cause severe gastrointestinal, kidney and liver disorders both in humans and in the livestock. Gramnegative bacterial lipopolysaccharide (LPS) is also reported to cause chronic inflammation of the gut and is capable of stimulating liver injury. However, plant-derived flavonoids such as chrysin (CHR) and luteolin (LUT) display many positive aspects, such as antiinflammatory and antioxidant properties.