Physiological disturbances in inflammatory and metabolic regulatory pathways leading to Equine Laminitis

Abstract

Equine laminitis is a complex and debilitating condition that severely compromises hoof health and equine welfare. This thesis investigates the physiological disturbances in inflammatory and metabolic pathways that lead to the development of laminitis, with a focus on the roles of vascular compromise, inflammation, enzymatic activity, and metabolic dysfunction. These pathways are discussed to highlight their impact on the laminar structures within the hoof capsule. It begins with a detailed summary of the anatomy and physiology of the equine hoof, emphasizing the role of the laminae in providing structural support and distributing mechanical forces during locomotion.