Effect of fermented wheat germ extract and proanthocyanidinson CYP 450 enzyme activity

Abstract

The cytochrome P450 enzymatic family, involved in the metabolism of different xenobiotics, has been in the focus of pharmacokinetic studies for a long time. Following oral administration, the bioavailability of the drugs can be altered by the oxidative processes catalyzed by the CYP450 enzymes. Different drugs, xenobiotics and nutrients may interact with each other when combined, thus they can induce or inhibit the CYP450 enzymes.