Az rhG-CSF használatának a szerotoninkoncentrációra gyakorolt rövid távú hatásai a macska panleukopeniájának kezelésében
Megtekintés/ Megnyitás
Dátum
2024-10Szerző
Erol, Büşra Burcu
Gülersoy, Erdem
Koral, Erman
DOI link
10.56385/magyallorv.2024.10.603-614Metaadat
Részletes rekordAbsztrakt
Feline panleukopenia (FP) is a highly contagious disease in cats, particularly affec-
ting young and unvaccinated ones. Conventional treatments have a success rate
below 50%. FPV severely impacts progenitor cells and all myeloid populations,
leading to panleukopenia, making immune stimulation vital for treatment. This
study aimed to evaluate the short-term effects of recombinant human granu-
locyte colony-stimulating factor (rhG-CSF, filgrastim) on FP and update treatment
protocols by assessing serum serotonin concentrations. 28 cats were treated: 14
with standard treatment and 14 with standard treatment plus filgrastim at 5 mcg/
kg twice daily. After 24 hours, granulocyte and serum serotonin concentrations
in the Filgrastim group were higher than those in both the first admission and
Standard treatment groups (p < 0.05). It was concluded that the administration of
filgrastim stimulates blood progenitor cells, alleviates immunosuppression, and
increases serum serotonin concentrations. Assessing serotonin concentrations
may provide insights into inflammation and serves as a prognostic indicator for
treatment response.