| dc.description.abstract | ÖSSZEFOGLALÁS
Az antimikrobiális peptidek (AMP-k) mint ígéretes, a hagyományos antibiotikumokat helyettesítő jelöltek, a gazdaszervezet sejtjeire kifejtett hatásaikkal
hozzájárulhatnak a baromfi kórokozóknak kitett bélrendszerének egészségéhez.
A szerzők a szakirodalom áttekintésével bemutatják, hogy az AMP-k szabályozhatják a bél immunfolyamatait, támogathatják a normál szöveti és sejtkapcsoló struktúrák meglétét, hatással lehetnek a bélrendszer redoxegyensúlyára,
sőt közvetlenül javíthatják az emésztési folyamatokat és a felszívóképességet.
E tulajdonságaikkal hozzájárulhatnak az állatok egészségének megőrzéséhez és
a termelés hatékonyságának növeléséhez.
SUMMARY
In the era of antimicrobial resistance, antimicrobial peptides (AMPs) have been
considered as promising candidates for replacing conventional antibiotics. In
addition to the ability to directly attack microbes, great significance has been
attached to the peptides’ indirect antimicrobial mode of action which allows
them to control the defense mechanisms of the host. Owing to these beneficial
effects, AMPs have recently aroused notable interest in the poultry sector, since
chickens are constantly challenged by a large set of enteral pathogens, and
maintaining gut health is of utmost importance to provide effective production.
Given that AMPs display multifaceted activity depending on the peptide of interest and the specific biological circumstances, their effects at a cellular level
in poultry species need to be thoroughly investigated. The present literature
review aimed to summarize the findings of studies examining the modulation of
chicken gut homeostasis and the enteral host cells after AMP-treatment. Based
on these relevant data, the authors established that gut health implies a highly
orchestrated system of various components, and AMPs can influence it in an
indirect antimicrobial manner. They can regulate enteral host cells and immune
state by affecting inflammatory mediators and immune cells, support normal
intestinal morphology and epithelial integrity, influence the oxidative state, or
even enhance digestive function and absorptive capability directly. As a result,
AMPs are suggested to contribute to animal health and well-being, as well as to
increased efficacy of meat and egg production in poultry farming. To conclude,
AMPs provide various benefits and may be promising alternatives for replacing
conventional antibiotics in livestock farming; however, more research is needed
to fully elucidate their mechanisms of action. | en_US |
