Ivóvízben adagolt tilvalozin hatékonyságának vizsgálata Mycoplasma hyopneumoniae okozta légzőszervi betegség kezelésére hízósertésekben

Abstract

The objective of this field trial was to investigate the efficacy of tilvalozin (TVN) administered via drinking water at a dose of 10 mg/kg bw for 5 days for the treatment and metaphylaxis of respiratory disease caused by Mycoplasma hyopneumoniae (hereafter: M. hyopneumoniae) for fattening pigs under farm conditions. The primary parameters were the cure rate of clinically ill pigs and the new incidence rate among in contact pen mates. The two groups consisted of mixed sex fattening pigs of the same age (16 weeks) housed in the same fattening barn in 11–11 pens (average 22 pigs per pen). In addition to M. hyopneumoniae, Pasteurella multocida, Glässerella parasuis and Mycoplasma hyorhinis were detected in bronchoalveolar fluid taken before the first treatment and Actinobacillus pleuropneumoniae was isolated from the lung of a dead pig. The TVN group received Aivlosin® 625 mg/g granules for use in drinking water for pigs (ECO Animal Health), while the clinically ill animals in the control group were treated with tylosin injection (Pharmasin 200 mg/ml inj. Huvepharma NV) at a dose of 10 mg/kg bw for 3 days. Clinically healthy pigs in the control group were not treated. Thus, the study was a positive (reference) controlled (noninferiority) from curative treatment and a negative (untreated) controlled from metaphylaxis point of view. The cure rate was 91.7% in the TVN group vs 86.7% in the positive control group, which was statistically significant equivalence. The incidence of new cases as well as the severity of the respiratory signs proved to be significantly lower in the TVN (0.9%, mean respiratory score 0.09) than in the negative (untreated) control group (4.5% and mean score of 0.26). The results support the efficacy of tylvalosin in a dose of 10 mg/kg bw via drinking water for the treatment and metaphylaxis of respiratory disease associated with M. hyopneumoniae under field conditions.