Deslorelin tartalmú implantátummal (Suprelorin® 4,7 mg) végzett kémiai kasztráció hatása a spermaminőségre, a testtömegre, a vér egyes biokémiai paramétereire és a vérképre ivarérett Beagle kan kutyákban - Irodalmi összefoglaló és saját tapasztalatok

Abstract

SUMMARY Background: Semen characteristics in frequently collected samples after insertion of a Suprelorin® 4.7 mg (Virbac, France) implant have not been reported yet. Objectives: to determine the effects of Suprelorin® 4.7 mg on the quality of semen collected twice weekly, and on metabolic function and health by body weight (BW) changes and serum biochemical (glucose, triglycerides, ALT, AP, BUN, creatinine, total protein, albumin, albumin/globulin ratio, electrolytes) and haematology analysis. Materials and Methods: Five adult healthy male Beagles (31-46 months old, 10.4-13.9 kg) housed together and fed the same ration throughout the study were implanted subcutaneously with 4.7 mg Suprelorin® (d0). Semen was collected twice weekly. DNA fragmentation index (% DFI) was determined with Sperm Chromatin Structure Assay (SCSATM). BW measurements and blood sampling were performed on d0, d21, and biweekly until d112. Data was analysed with general linear model with repeated measures. Results and Discussion: BW was stable and haematology and biochemical parameters remained in the normal range. In 4 dogs semen could be collected until d10 and until d17 in the last dog. No changes in ejaculate volume, sperm concentration, total number of spermatozoa, progressive motility, morphology and % DFI (1.33-4.50% frozen-thawed 0 h, 1.49-6.66% frozen-thawed after 3 h incubation at 38 °C) were detected (P≥0.112).. As semen quality was not significantly influenced, matings may result in viable offspring until aspermia occurs. Under controlled feeding conditions, 4.7 mg Suprelorin® administration does not result in BW changes and in any alterations of blood parameters.