Az rhG-CSF használatának a szerotoninkoncentrációra gyakorolt rövid távú hatásai a macska panleukopeniájának kezelésében

Abstract

Feline panleukopenia (FP) is a highly contagious disease in cats, particularly affec- ting young and unvaccinated ones. Conventional treatments have a success rate below 50%. FPV severely impacts progenitor cells and all myeloid populations, leading to panleukopenia, making immune stimulation vital for treatment. This study aimed to evaluate the short-term effects of recombinant human granu- locyte colony-stimulating factor (rhG-CSF, filgrastim) on FP and update treatment protocols by assessing serum serotonin concentrations. 28 cats were treated: 14 with standard treatment and 14 with standard treatment plus filgrastim at 5 mcg/ kg twice daily. After 24 hours, granulocyte and serum serotonin concentrations in the Filgrastim group were higher than those in both the first admission and Standard treatment groups (p < 0.05). It was concluded that the administration of filgrastim stimulates blood progenitor cells, alleviates immunosuppression, and increases serum serotonin concentrations. Assessing serotonin concentrations may provide insights into inflammation and serves as a prognostic indicator for treatment response.